Modern cosmetology has a whole range of techniques and
techniques that can significantly rejuvenate the skin. Worth it is true
note that almost all existing methods are capable of
to rejuvenate the skin only for a time, without at all affecting
biological processes occurring in the cells. But we know that
aging begins at the cellular level and act wisely
it is on the cells to reverse this process. Therefore, in
cosmetology there are regenerative technologies that
based on involutional biotechnology. Main tool
regenerative technologies are fibroblasts.
- What is fibroblasts
- Functions of fibroblasts
- How to activate fibroblasts?
- Modern regenerative technologies
- Fibroblasts, stem cells and oncogenesis
What is fibroblasts
Fibroblasts are connective tissue cells that
synthesize the extracellular matrix. Fibroblasts secrete
precursors of collagen and elastin, as well as glycosaminoglycans,
the most famous of which is hyaluronic acid. Fibroblasts
are germinal tissue in both humans and animals.
Fibroblasts have a diverse form, depending on
location in the body and the level of its activity. Word
“fibroblasts are derived from the Latin root” fiber “- fiber
and the Greek “blastos” – the germ.
Functions of fibroblasts
The main role of fibroblasts in the body – the synthesis of components
- proteins (collagen and elastin) that form
- mucopolysaccharides (amorphous substance).
In the skin, fibroblasts are responsible for its recovery and
updates. They synthesize collagen and elastin – the main frame
skin and hyaluronic acid that binds water in tissues. Other
In other words, fibroblasts are the generators of youth and
the beauty of our skin. Over the years, the number of fibroblasts decreases, and
the remaining fibroblasts lose their activity. For this reason
the rate of regeneration of the skin decreases, collagen and elastin
lose their ordered structure, resulting in
more damaged fibers unable to perform their straight
functions. As a result, age wilting of the skin begins: flabbiness,
dryness, loss of volume and the appearance of wrinkles.
Under the influence of UV radiation in the skin free radicals are formed,
destructive collagen and elastic fibers. But not only
free radicals destroy collagen and elastin. In the process
collagen and elastin destruction are also involved enzymes
collagenase and elastase, which are also synthesized by fibroblasts.
Enzymes break down protein fibers into major components, from
which then fibroblasts produce collagen precursors and
Fibroblasts can be said to play a key role in the process.
the cycle of degradation and synthesis of cells and fibers.
Let’s call the main functions of fibroblasts in the body:
- promote epithelialization and healing of damaged skin
keratinocyte stimulation score;
- accelerate cell proliferation and differentiation;
- play a large role in wound healing, promote movement
- synthesize collagen, elastin and hyaluronic acid;
- participate in the regeneration and renewal of skin
How to activate fibroblasts?
We have learned above what causes aging of the body, and what role
in this process are fibroblasts. And here it is born quite
a natural question: how to activate fibroblasts? After all, with
their age does not just decrease, even if the number
fibroblasts remain the same, they become passive and
completely lose their activity. The task of regenerative
biotechnology to find ways to influence fibroblasts in order to
make them “remember youth”. Is there any success in this
direction? Surely, yes.
Replenishment in the skin of youth proteins – collagen and elastin –
injection method does not give reliable results
rejuvenation. They are able to improve the characteristics of the skin only on
some time. That is, the skin condition is getting better, but
the aging process is not suspended, the biological clock is inexorable
go ahead. And after a while, after collagen degradation,
elastin and hyaluronic acid, the skin condition leaves much to be
The best means of rejuvenation is our natural system.
renewal and regeneration. Stimulation of the body’s own resources
– this is the key to our youth. At the moment there are
regenerative biotechnologies that can truly rejuvenate
an organism. The main role in these techniques is given
Modern regenerative technologies
The basis of modern regenerative technologies is the principle
stimulation of autologous dermal fibroblasts. The essence of these
technology is to replenish the fibroblast population of young
and active cells. This method is called SPRS-therapy, which
literally stands for service for personal regeneration of skin
(service for individual skin recovery).
How does this happen? From a piece of skin by certain
laboratory manipulations emit fibroblasts. Selection and stimulation
only young and active fibroblasts are exposed. Then them
the population has been brought to the necessary volumes for some time,
and they are ready for introduction into the body. When introducing autologous
(own) fibroblasts there is no rejection and
allergic reactions, as the body receives its own
own cells. New fibroblasts are able to regenerate
integuments for two years and even more. The result is noticeable
immediately after the first session of cell therapy. Going on
noticeable improvement of the skin: the flabbiness and dryness disappear,
complexion and structure of skin improves, small ones completely disappear
wrinkles, and deep ones become less noticeable.
Fibroblasts, stem cells and oncogenesis
Many patients identify fibroblasts with stem
by cells. Therefore, it is often asked whether fibroblasts are not
stem cells? No no and one more time no. Fibroblasts are not
have nothing to do with stem cells, use
which, by the way, is prohibited worldwide. Fibroblasts
are mature, specialized for a particular fabric
cells. They can only turn into fibroblasts. Fibroblasts –
These are also cells of the connective tissue that cannot divide.
Stem cells are immature, undifferentiated cells,
which can give rise to several cell types and of which
You can grow any tissue of our body.
Another question frequently asked by patients is whether
autologous fibroblasts reborn into tumor cells? it
completely impossible. Fibroblasts are not able to be reborn in
malignant cells because they are not amenable
indirect cell mitigation (mitosis). They are programmed to
a certain number of divisions, after which they die, and their place
occupy new cells. After penetration into the skin, fibroblasts do not
divided, but for a long time produce the necessary
substances that promote regeneration and rejuvenation of the skin. So
thus, they remain completely safe autologous
fibroblasts as in the process of cultivation in the laboratory,
and in the process of introduction into the body.
Cultivated autologous fibroblasts are subject to strict
biosafety and viability monitoring