Prebranch Melanosis of Dubrae or Malignant Lentigo is
a disease that is characterized by the appearance on the skin
neoplasms in the form of age spots, moles (nevus) or
tight knot. Dubrae’s Melanosis is a cluster
pigment cells that are localized in both the dermis and
epidermis. Usually the boundaries of the formation are even, clear, surface.
may be smooth or papillomatous light brown or
black color. The disease develops most often in older people.
with fair skin. It is noteworthy that this pathology is practically
does not affect members of the Negroid race. Melbiasis of Dubreus
occurs with the same frequency of both men and women. but
Nevertheless, the disease is less common in men than in women. Have
men the disease develops at the age of 50-60 years, in women in
This pathology causes some controversy among specialists.
Some of the slopes are considered Dubus melanosis a nevus, others refer it to
senile dermatosis. However, all experts agree
that this pathology has a high low-hazard threshold and
needs serious treatment.
According to the international classification of skin tumors,
Dubrean’s melanosis, like Bowen’s disease, is considered in situ cancer
(cancer in situ), that is, obligate, preinvasive cancer
disease. This form is a very early stage.
malignant disease that implies congestion
atypical cells in the tumor, but without germination in the underlying tissue
or internal organs.
- Causes of development
- Symptoms and stages of development
- Prognosis and prevention
Causes of development
Unfortunately, no exact reasons have been identified yet.
contribute to the development of Melanosis Dubraea. But indirect ones are known.
reasons that can trigger the development of this disease. Him
development is determined by endogenous factors:
- increased susceptibility to ultraviolet (I, II, III phenotype
- age after 50 years;
- the presence of keratosis;
- the presence of elastosis;
- atrophy of the skin.
- excessive ultraviolet radiation;
- draining the skin as a result of its dehydration;
- excessive abuse of tan obtained as in
the natural environment and in the solarium;
- damage and injury to the skin.
Symptoms and stages of development
Dubreus’s melanosis is a pigment spot or knot,
which has an uneven color, a diverse form, but clear
boundaries. Its shades can vary from light brown to
black color. Favorite localization of melanosis is open
skin patches, especially the face. Also melanosis can be localized
on the skin of the eyelids and even on the conjunctiva of the eyes. Melanosis develops
long enough, sometimes it takes years and even decades. But,
despite such a comforting sign, vertical growth of melanosis
presents some concerns as in this case occurs
his compulsory rebirth into melanoma.
You should immediately visit a doctor if you notice
The following are signs indicating the transformation of melanosis into
- intensive tumor growth;
- the appearance of jagged or wavy borders;
- the appearance of areas of skin atrophy;
- the appearance on the affected area of papules and nodes (which previously
did not have);
- changing the shape, size and structure of the spot.
Most often, the pathology develops in the form of single elements
mainly in the elderly. With malignancy spots, usually
occurs a few years after the first manifestation
diseases, its increase occurs, darker ones appear
plots and formed dolkoobrazny papillomas.
There are several stages of development of this disease:
- The first stage, which is called Efelida (freckle),
manifested by an increase in the number of cells – melanocytes.
- The second stage – lentigo implies changes in the structure
melanocytes in other words atypical accumulate
changes in melanocytes.
- The third stage – dysplasia is manifested by growing into the dermis
The disease is easily diagnosed by clinical manifestations. But
if melanoma is suspected, a whole range of laboratory tests are performed.
- biopsy and morphological examination;
- check for tumor markers.
With the help of a special apparatus, which increases by several
once the surface image of the tumor, you can consider the slightest
change its shape, structure and size. When performing a biopsy and
morphological studies observed acanthosis and increased
melanocyte concentration. Radioactive Phosphorus Scintigraphy
allows you to accurately determine the development of melanoma. Oncomarkers –
these are substances that are found in the patient’s blood or urine
specific proteins produced by malignant cells
It is necessary to conduct a differential diagnosis with the following
- seborrheic keratosis;
- verrucous nevus
- senile keratosis.
Due to the high risk of malignancy of the tumor, people with melanosis
Dubrae should be observed by a dermato-oncologist for years. When
suspected malignancy melanosis is performed surgical
treatment which consists in excision of the tumor with removal
In the case of an inoperable form of skin cancer, radiation is used.
therapy. Namely, close-focus radiotherapy.
Prognosis and prevention
The earlier the diagnosis is made, the better the prognosis. Sure to
the treatment of Melanosis of Dubrae should be carried out, since without treatment
75% of cases of melanosis turn into the malignant form of melanoma (
letigo – melanoma). In very rare cases, spontaneous
spontaneous healing. That is, melanosis passes by itself
Prevention for this disease does not exist, so
how not clear reasons for its occurrence. Compulsory
is the fact of protecting the skin from ultraviolet radiation and direct
sun rays on moles, pigment spots and other